Reginald Sanjay Pal Research Interests
We are trying to understand the biology of the extracellular matrix (ECM) in health and disease relevant to India with special reference to malnutrition. Focus is on cell adhesion protein fibronectin and its interaction with different cell surface proteins from both host (MMP-2, heparin, collagen) and guest [fibronectin/collagen binding proteins (FBP /CBP) from microbes]. The broad themes are:
- Matrix binding proteins from probiotics and viruses:
We are screening different potential probiotic microbes from popular and affordable fermented food and beverages, which bind to denatured collagen (gelatine) and fibronectin. The goal is to design better probiotics, peptides drugs which will compete against the host -pathogen interaction at cell surface and also to design bacteriophages which will compete/kill the enteric pathogens (Sanitation Biotechnology). - Characterization of Fibronectin isoforms and proteolytic fragments affecting cell behaviour (cell morphology, migration, proliferation)
- Factors affecting gelatinase (MMP-2) mediated fragmentation of fibronectin
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